THE FOUNDATION OF A HEP C TREATMENT REVOLUTION

SOVALDI is a prescription medicine used with other antiviral medicines to treat adults with chronic (lasting a long time) hepatitis C (Hep C) with or without cirrhosis (compensated). In those with Hep C genotype (GT) 1 or 4 infection, SOVALDI is used in combination with peginterferon alfa and ribavirin. In those with GT 2 or 3 infection, SOVALDI is used in combination with ribavirin. It is not known if SOVALDI is safe and effective in adults who have had a liver transplant.

The 2013 arrival of SOVALDI combination therapy marked the beginning of a Hep C treatment transformation. Over 100,000 patients have been prescribed SOVALDI.* SOVALDI was—and continues to be—a clear step forward in Hep C treatment.

Have you been prescribed combination therapy with SOVALDI?

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*This information is derived from IMS NPA, IMS NSP™, and IntegriChain® data; data reflect estimated patient starts for SOVALDI from December 2013–September 2016.

SOVALDI is a prescription medicine used with other antiviral medicines to treat adults with chronic (lasting a long time) hepatitis C (Hep C) with or without cirrhosis (compensated). In those with Hep C genotype (GT) 1 or 4 infection, SOVALDI is used in combination with peginterferon alfa and ribavirin. In those with GT 2 or 3 infection, SOVALDI is used in combination with ribavirin. It is not known if SOVALDI is safe and effective in adults who have had a liver transplant.

Important Safety Information

What is the most important information I should know about SOVALDI?

SOVALDI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting SOVALDI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with SOVALDI. This may cause serious liver problems, including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking SOVALDI.

What should I tell my healthcare provider before taking SOVALDI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if SOVALDI will harm your unborn baby or pass into your breast milk. If you take SOVALDI in combination with ribavirin or with peginterferon alfa and ribavirin, you should also read those Medication Guides for important pregnancy-related information.

Continued below

Continuing to transform treatment

SOVALDI is sofosbuvir, a breakthrough drug that has changed the way Hep C is treated. Since the arrival of SOVALDI, sofosbuvir-based treatment has evolved to include:

This information is derived from IMS NPA, IMS NSP™, and IntegriChain® data; data reflect estimated patient starts for HARVONI from October 2014–September 2016.

Important Safety Information

What should I tell my healthcare provider before taking SOVALDI? (continued)

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOVALDI and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of SOVALDI?

Serious side effects may also include:

  • Slow heart rate (bradycardia): SOVALDI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with SOVALDI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of SOVALDI used in combination with ribavirin include tiredness and headache and when used in combination with peginterferon alfa and ribavirin they include the additional side effects of nausea, difficulty sleeping, and low red blood cell count.

Please see Important Facts about SOVALDI including Important Warning.

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HARVONI® (ledipasvir 90 mg/sofosbuvir 400 mg) Learn more at HARVONI.com

What is HARVONI?

HARVONI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype (GT) 1, 4, 5 or 6 infection with or without cirrhosis (compensated). In those with GT 1 and advanced cirrhosis (decompensated) or with GT 1 or 4 with or without cirrhosis (compensated) who have had a liver transplant, HARVONI is used with ribavirin.

Important Safety Information

What is the most important information I should know about HARVONI?

HARVONI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting HARVONI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with HARVONI. This may cause serious liver problems, including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking HARVONI.

What should I tell my healthcare provider before taking HARVONI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of HARVONI?

Serious side effects may also include:

  • Slow heart rate (bradycardia): HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of HARVONI include tiredness, headache, and weakness.

Please see Important Facts about HARVONI including Important Warning on hepatitis B reactivation.

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EPCLUSA® (sofosbuvir 400 mg/velpatasvir 100mg tablets) Learn more at EPCLUSA.com

What is EPCLUSA?

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Important Safety Information

What is the most important information I should know about EPCLUSA?

EPCLUSA can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

What should I tell my healthcare provider before taking EPCLUSA?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of EPCLUSA?

Serious side effects may also include:

  • Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of EPCLUSA include headache and tiredness. Tell your healthcare provider if you have any side effect that bothers you or does not go away.

Please see Important Facts about EPCLUSA including Important Warning on hepatitis B reactivation.

SOVALDI is a prescription medicine used with other antiviral medicines to treat adults with chronic (lasting a long time) hepatitis C (Hep C) with or without cirrhosis (compensated). In those with Hep C genotype (GT) 1 or 4 infection, SOVALDI is used in combination with peginterferon alfa and ribavirin. In those with GT 2 or 3 infection, SOVALDI is used in combination with ribavirin. It is not known if SOVALDI is safe and effective in adults who have had a liver transplant.

Important Safety Information

What is the most important information I should know about SOVALDI?

SOVALDI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting SOVALDI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with SOVALDI. This may cause serious liver problems, including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking SOVALDI.

What should I tell my healthcare provider before taking SOVALDI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if SOVALDI will harm your unborn baby or pass into your breast milk. If you take SOVALDI in combination with ribavirin or with peginterferon alfa and ribavirin, you should also read those Medication Guides for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOVALDI and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of SOVALDI?

Serious side effects may also include:

  • Slow heart rate (bradycardia): SOVALDI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with SOVALDI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of SOVALDI used in combination with ribavirin include tiredness and headache and when used in combination with peginterferon alfa and ribavirin they include the additional side effects of nausea, difficulty sleeping, and low red blood cell count.

Please see Important Facts about SOVALDI including Important Warning.

SOVALDI, the SOVALDI logo, HARVONI, the HARVONI logo, EPCLUSA, the EPCLUSA logo, SUPPORT PATH, the SUPPORT PATH logo, GILEAD, and the GILEAD logo are trademarks of Gilead Sciences, Inc., or its related companies. All other trademarks referenced herein are the property of their respective owners.
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