Sovaldi: A clear step forward in Hep C treatment

How does SOVALDI work?

SOVALDI is sofosbuvir—a breakthrough medicine that directly targets the hepatitis C (Hep C) virus. Combination therapy with SOVALDI has been shown to be effective for people with Hep C genotypes 1, 2, 3, and 4.

What is a genotype?

Just as there are different blood types, there are also different types of Hep C, called genotypes. There are 6 main genotypes. SOVALDI has been shown to work in genotypes 1, 2, 3, and 4. SOVALDI combination therapy is the first all-oral treatment for genotypes 2 and 3.

Your healthcare provider can use a simple blood test to find out your type. Knowing your genotype can help your healthcare provider choose the right treatment for you. It can also affect the length of your treatment and your chance of being cured. Cure means the Hep C virus is not detected in the blood when measured 3 months after treatment is completed.

Hep C percentages in the U.S. by genotype

  • Genotype 1—78%
  • Genotype 2—13%
  • Genotype 3—6%
  • Other Genotypes—3%

What the Hep C virus does

The Hep C virus infects a liver cell. Then, it uses the cell to create new copies of itself. These copies then leave the cell and move on to infect other liver cells, creating more copies.

What sofosbuvir does

Sofosbuvir directly targets the Hep C virus to stop it from making copies of itself in the liver. Sofosbuvir attaches itself to the genetic information, called RNA, to block the virus from multiplying.

SOVALDI is a prescription medicine used with other antiviral medicines to treat chronic (lasting a long time) hepatitis C genotype 1, 2, 3, or 4 infection in adults. It is not known if SOVALDI is safe and effective in children under 18 years of age.

Important Safety Information

What should I tell my healthcare provider before taking SOVALDI?

  • If you have: liver problems other than hepatitis C infection; had a liver transplant; severe kidney problems or are on dialysis; HIV; any other medical condition; are pregnant or plan to become pregnant; or if you are breastfeeding or plan to breastfeed. It is not known if SOVALDI passes into your breast milk.
  • If you take amiodarone (Cordarone®, Nexterone®, Pacerone®), rifampin (Rifadin®, Rifamate®, Rifater®), St. John’s wort or a product that contains St. John’s wort. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how SOVALDI works.

You should not take SOVALDI if you also take other medicines that contain sofosbuvir (HARVONI®).

What are the most common side effects of SOVALDI?
For SOVALDI used in combination with ribavirin they include tiredness and headache and for SOVALDI used in combination with peginterferon alfa and ribavirin they include the additional side effects of nausea, difficulty sleeping, and low red blood cell count.

SOVALDI, the SOVALDI logo, HARVONI, ONWARD, the ONWARD logo, SUPPORT PATH, the SUPPORT PATH logo, GILEAD, and the GILEAD logo are trademarks of Gilead Sciences, Inc., or its related companies. All other trademarks referenced herein are the property of their respective owners.
©2016 Gilead Sciences, Inc. All rights reserved. SVDC0302 12/16

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SOVALDI is a prescription medicine used with other antiviral medicines to treat chronic (lasting a long time) hepatitis C genotype 1, 2, 3, or 4 infection in adults. It is not known if SOVALDI is safe and effective in children under 18 years of age.

Important Safety Information

What should I tell my healthcare provider before taking SOVALDI?

  • If you have: liver problems other than hepatitis C infection; had a liver transplant; severe kidney problems or are on dialysis; HIV; any other medical condition; are pregnant or plan to become pregnant; or if you are breastfeeding or plan to breastfeed. It is not known if SOVALDI passes into your breast milk.
  • If you take amiodarone (Cordarone®, Nexterone®, Pacerone®), rifampin (Rifadin®, Rifamate®, Rifater®), St. John’s wort or a product that contains St. John’s wort. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how SOVALDI works.

You should not take SOVALDI if you also take other medicines that contain sofosbuvir (HARVONI®).

What are the most common side effects of SOVALDI?
For SOVALDI used in combination with ribavirin they include tiredness and headache and for SOVALDI used in combination with peginterferon alfa and ribavirin they include the additional side effects of nausea, difficulty sleeping, and low red blood cell count.